Jimmy Winterpock at age fourteen is 5'5 and weighs 187 pounds. Outside the comfort of his family and church, life for Jimmy is a constant struggle. The cruel taunts of his classmates make going to school or playing sports a humiliating experience. Yet, he still manages to focus on his goals; to lose weight and win over the girl of his dreams.

A simple man, Dr. Walter Newman, has high aspirations to cure all disease through genetic manipulation. His obsession with his mission draws him deeper into his own dark world, distracting him from his wife Olivia and from his responsibilities to his patients at the Edgewood Asylum. The doctors loyal but diabolical nurse, Ms. Tinsley, decides to take matters into her own hands and in secret she conducts her own experiment. When Dr. Newman realizes what has been done, a deformed creature that defies nature is created. Part human, part nightmare. Dr. Newman knows what he must do, but is it already too late?