Soon after her return from a business trip to Hong Kong, Beth Emhoff dies from what is a flu or some other type of infection. Her young son dies a few days later. Her husband Mitch however seems immune. Thus begins the spread of a deadly infection. For doctors and administrators at the U.S. Center for Disease Control, several days pass before anyone realizes the extent or gravity of this new infection. They must first identify the type of virus in question and then find a means of combating it, a process that will likely take several months. As the contagion spreads to millions of people worldwide, societal order begins to break down as people panic.

Black Ops operative Malcolm Gray returns home after a botched mission in Eastern Europe. Holed up in a Brooklyn motel room, he is torn between retribution and personal salvation as he mentally unravels. When the walls close in, his story may be all he can leave behind.

Batman raises the stakes in his war on crime. With the help of Lieutenant Jim Gordon and District Attorney Harvey Dent, Batman sets out to dismantle the remaining criminal organizations that plague the city streets. The partnership proves to be effective, but they soon find themselves prey to a reign of chaos unleashed by a rising criminal mastermind known to the terrified citizens of Gotham as The Joker.