Uncertainty results in the life of Delhi-based Raj when his wealthy wife, Kiran, the sole heir to the Saxena Group of Companies, finds out that he may be having an affair with leggy model, Dolly, who is being stalked by her possessive ex-boyfriend, Diesel. Kiran hires a private detective, Nunnu, who secretly loves her, to follow Dolly and Raj around. To pull wool over their eyes, Raj recruits a former waiter, Goverdhan, to pose as Dolly's live-in boyfriend, while an embittered former employee, Mangu, prepares to blackmail Raj. Hilarious chaos results when Raj starts to suspect that Goverdhan and Dolly are having an affair.

Indian-born Manmohan Malhotra decided to re-locate to London, England, established himself, returned to India, got married to Bebo, and after a period of 4 years got a visa for her so that she could live with him. Shortly thereafter she gave birth to Jasmeet. Manmohan was always embarrassed of Bebo, as she was overly healthy and not quite sophisticated, as a result he always left her at home, while he socialized. Bebo did not want Jasmeet to end up like her, so got her admitted in an English Medium school, encouraged to mingle with Caucasian friends, and as a result Jasmeet was transformed in to Jazz - a stunningly beautiful young woman, British in looks, talk, habits, and heart. Manmohan's plans to get her married to an Indian boy are all in vain. His friend, Parvez Khan, is in a similar situation with his son, Imran, openly romancing a Caucasian blonde, Susan. Manmohan decides to take his family for a tour in India...

Karan Pandey and Rahul are two friends who work in a fashion designers office, and live in a rented apartment. When they are unable to pay the rent, they are dramatically evicted, but sneak their way back in within hours as the building is being renovated. Karan meets a beautiful woman, Kiran, and falls in love with her. He finds out that she is the girlfriend of his boss, D.K. Bose, lives in a bungalow in Malabar Hill, and owns a Mercedes. When Bose leaves for a business trip to America, Karan and Rahul move into his apartment and through his telephone Karan touches base with Kiran and begins his romance with her. In the meantime, Rahul is told by a street astrologer that he will find his soul-mate in a girl who has a birthmark on her right breast. Rahul does not find one but several women with a mark on their breast, and does recover from several embarrassing incidents. Then beautiful Urmila Martodkar walks into his life...

Four slackers and con-men namely: Boman Contractor, who lives a wealthy lifestyle with his eccentric dad, Nari, who loves his antique car more than his son, and asks his son to leave when he damages the car; hot-headed Aditya and dim-witted Manav, orphaned brothers; and Deshbandhu Roy, a trickster who wears a magnetized belt; share a room with a lenient landlady, who eventually gives up on them and kicks them out. After a number of con tricks, the group are arrested by the Police, but released in the countryside. At this point they witness a car plummet down a cliff, with it's sole occupant, Bose, an underworld don, who, before dying, tells them that he has hidden 10 Crore Rupees in cash in the St. Sebastian's Garden, Goa, and if they find it, it is their's to keep. The group race toward Goa in Contractor's stolen car, little knowing that their plans will soon be foiled...

Arush Mehra lives a fairly wealthy lifestyle in Sydney, Australia along with two room-mates, Tanmay Joglekar, and Ali Hyder. He works for a food chain, while Tanmay entertains children as 'Eddy Teddy', and Ali takes care of their apartment. All three are womanizers and usually end up sleeping with around 30 different women every year. Arush travels to Delhi to attend Arjun's wedding, and this is where he meets with Isha Sahni, who also resides in Australia, he impresses and wins her over, both get intimate, and shortly thereafter Isha catches him sleeping with Devika, and both split up. Arush returns to Sydney and forgets about this incident. Then one day they find a baby right outside their door with a note to take care of her. The trio suspect each other of being the father, then attempt to get rid of the child, but change their mind, look after her, name her Angel, adore her...

Housefull is a romantic comedy entertainer which narrates the story of Aarush - the world's unluckiest man. Being jinxed, he believes his bad luck can vanish if he finds true love. In this quest for true love how one lie leads to another and how different people from different walks of life come together adding even more confusion to this hilarious comedy of errors resulting in total chaos and mayhem forms the crux of the story. The line which Deepika tells Akshay in the film "Jis jhooth se kissi ka ghar basta ho, voh jhooth jhooth nahin hota", pretty much sums up the essence of the film.