Jason Gedrick and a small group of Marines are stranded in the remote Afghan desert. But it ain't the Taliban that's worrying them, it's these giant refugees from Tremors. In fact the big worms prove to be an ally of sorts by doing better against the Taliban than themselves but battling these enemies is something not covered in their training.

On her first trip to Paris, a young woman hits a party in the Catacombs, the 200-mile labyrinth of limestone tunnels under the city that's lined with the remains of 7 million people. Separated from her friends, she becomes convinced that someone or something is chasing her.

On the coast of Cork, Syracuse is a fisherman, on the wagon, living alone. His precocious daughter, Annie, about 10, has failing kidneys. One day, a nearly-drowned young woman comes up in his net; she speaks oddly, calls herself Ondine, and wants no one to see her. He puts her up in an isolated cottage that was his mother's. Annie discovers Ondine's presence and believes she's a selkie, a mythical seal turned human while on land. If this is a fairy tale, is there a happily ever after, or do the realities of alcohol, illness, and worse intrude, including Syracuse's inveterate bad luck? As his priest tell him, misery's easy, it's happiness you have to work at. Any hope of that?

In London, the sideshow troupe of Doctor Parnassus promises the audience a journey to the "Imaginarium", an imaginary world commanded by the mind of Doctor Parnassus, where dreams come true. In the stories that Doctor Parnassus tells to his daughter Valentina, the midget Percy, and his assistant Anton, he claims to have lived for more than one thousand years; However, when he fell in love with a mortal woman, he made a deal with the devil (Mr. Nick), trading his immortality for youth. As part of the bargain, he promised his son or daughter to Mr. Nick on their sixteenth birthday. Valentina is now almost to the doomed age and Doctor Parnassus makes a new bet with Mr. Nick, whoever seduces five souls in the Imaginarium will have Valentina as a prize. Meanwhile the troupe rescues Tony, a young man that was hanged on a bridge by the Russians. Tony was chased until he finds and joins the group...

After receiving mysterious empty packages inside his apartment, a young computer-programmer (named Simon) begins a personal investigation into their origins. This leads him to discover his odd and eccentric neighbors; an artificially intelligent robot-head, named Adam; a virtual-reality sex game; and a possible corporate conspiracy. As the story progresses, Simon's grip on reality becomes more and more tenuous, while his craving for Nature Fresh milk becomes almost unbearable. Is it all just in his mind, or is something more sinister happening here?

Picking up immediately where Anaconda 3 left off, herpetologist Amanda Hayes finally learns her employer Murdoch's true colors when he hires a doctor to harvest a fresh supply of blood orchids to experiment with the regenerative nectar on a baby snake in order to seek treatment for his own terminal illness. Amanda is forced to secretly bring together another team of scientists whom face off against a heavily armed squad of Murdoch's men to steal the coveted orchids before the killer Anaconda hunts both parties down.