Eliza Kendall Welch (Uma Thurman), mother of, Clara, and Lucas, lives with her spouse, Avery McKendrik (Anthony Edwards), in an Manhattan apartment. Today is May 25th, Clara's 6th birthday, and she has to make arrangements for a party, as well as attend to day-to-day chores, including Blogging, and entering an online contest 'Motherhood', and looking after her invalid elderly neighbor and a dog. Things will slowly get out of hand after her car gets towed due to a film shooting; the tire on her bike gets punctured; she alienates herself from her friend, Sheila (Minnie Driver); Clara's name is misspelled on the cake; while Avery refuses to answer his cell-phone. After being assisted by a delivery man, Nikesh (Arjun Gupta), who finds her attractive, she concludes she has had enough, and decides not to return home.

In Talbot, Ohio, a father's need for surgeries puts the family in a financial bind. His son Vince, an electrician, overhears a man talking about making a fortune in just a day. When the man overdoses on drugs, Vince find instructions and a cell phone that the man has received and substitutes himself: taking a train to New York and awaiting contact. He has no idea what it's about. He ends up at a remote house where wealthy men bet on who will survive a complicated game of Russian roulette: he's number 13. In flashbacks we meet other contestants, including a man whose brother takes him out of a mental institution in order to compete. Can Vince be the last one standing?

Enduringly traumatized by the disappearance of her 3-year-old daughter 15 years ago, Julia Sandburg has cut herself off from anyone once near and dear to her, including her husband Doug and her son Chris, who tried for years to penetrate her wall of isolation and despair, without success. But when Julia meets Louise, a troubled young woman with a checkered past, all Julia's old psychic wounds painfully resurface, as does her illogical and increasingly irrational hope that Louise may be the daughter she lost so long ago.

It has taken 10 years, two little Fockers with wife Pam (Polo) and countless hurdles for Greg to finally get "in" with his tightly wound father-in-law, Jack. After the cash-strapped dad takes a job moonlighting for a drug company, however, Jack's suspicions about his favorite male nurse come roaring back. When Greg and Pam's entire clan-including Pam's lovelorn ex, Kevin (Owen Wilson)-descends for the twins' birthday party, Greg must prove to the skeptical Jack that he's fully capable as the man of the house. But with all the misunderstandings, spying and covert missions, will Greg pass Jack's final test and become the family's next patriarch...or will the circle of trust be broken for good?

A New York schoolteacher hits a midlife crisis when, in quick succession, her husband leaves, her adoptive mother dies and her biological mother, an eccentric talk show host, materializes and turns her life upside down as she begins a courtship with the father of one of her students.