Sex is a background to examine intimacy and vulnerability. Looks at the complexity of modern day relationships told through eight separate couples. Through dialogue and compromising situations, the film takes us from the beginning of a relationship to the aftermath of one, and examines every stage in between seeing humor within the drama, heartache and confusion of it all.

Just before he's to marry Fiona, Roderick Blank receives an anonymous e-mail with 101 names on it; Fiona's is the 29th, the first 28 are women Rod has slept with, and the 30th turns out to be the stripper at his bachelor party. The notion that he will have sex with 70 more people sends Rod into crisis mode, especially after three odd men in an aseptic office confirm that a celestial machine has made an error. They suggest destroying the list, but Rod finds that easier said than done. Working his way through it consumes him, plus he realizes that death may await him after #101. Meanwhile, a femme fatale nicknamed Death Nell is putting men into a coma. Are they fated to meet?