Charlie St. Cloud is a young man overcome by grief at the death of his younger brother. So much so that he takes a job as caretaker of the cemetery in which his brother is buried. Charlie has a special lasting bond with his brother though, as he can see him. Charlie meets up with his brother (Sam) each night to play catch and talk. Then, a girl comes into Charlie's life and he must choose between keeping a promise he made to Sam, or going after the girl he loves

In Manhattan, twenty-two year-old Harvard lawyer Emilia Greenleaf has a crush on her boss, Jack Woolf, and they have an affair. Jack's marriage is a sham but his son, William, is his pride and joy. Emilia soon discovers she's pregnant, and Jack divorces his wife, Carolyn, in order to marry her. His son is poisoned against the partnership by his mother, and resented by his stepmother. Emilia, who has issues with her womanizer father, delivers Isabel but the baby dies. The marriage begins to suffer and William unexpectedly steps in to help.

Small-town detective Noah Cordin is called to solve a juvenile homicide that occurred during a home burglary in his affluent town of Hilliard. The dead boy's mother, Allison Connor, is a member of the Meskada County Board of Commissioners, and a powerful woman in Hilliard; and the entire township rallies together in solidarity - to support her and Detective Cordin's efforts to find the killers.

In Montgomery County, Kelly Taylor is ready to go to college and takes her autistic brother, Tom, to a specialized institution. However, the bank informs her that she does not have sufficient funds in her account to honor her check. Her stepfather, Johnny Gaveneau, withdrew the money from her account the day before. When Kelly arrives home, Johnny reveals that he used the money to buy a tiger for his 'safari show' project. In addition he has the house reinforced, in order to protect it from hurricanes, so all the windows and external doors are covered with wood. When Kelly awakes, she finds that the starving tiger is inside the house and Tom and she are trapped with the ravenous animal.

Adrienne Willis, a woman with her life in chaos, retreats to the tiny coastal town of Rodanthe, in the Outer Banks of North Carolina, to tend to a friend's inn for the weekend. Here she hopes to find the tranquility she so desperately needs to rethink the conflicts surrounding her -- a wayward husband who has asked to come home, and a teen-aged daughter who resents her every decision. Almost as soon as Adrienne gets to Rodanthe, a major storm is forecast and a guest named Dr. Paul Flanner arrive. The only guest at the inn, Flanner is not on a weekend escape but rather is there to face his own crisis of conscience. Now, with the storm closing in, the two turn to each other for comfort and, in one magical weekend, set in motion a life-changing romance that will resonate throughout the rest of their lives.

Robert Neville is a scientist who was unable to stop the spread of the terrible virus that was incurable and man-made. Immune, Neville is now the last human survivor in what is left of New York City and perhaps the world. For three years, Neville has faithfully sent out daily radio messages, desperate to find any other survivors who might be out there. But he is not alone. Mutant victims of the plague -- The Infected -- lurk in the shadows... watching Neville's every move... waiting for him to make a fatal mistake. Perhaps mankind's last, best hope, Neville is driven by only one remaining mission: to find a way to reverse the effects of the virus using his own immune blood. But he knows he is outnumbered... and quickly running out of time.