This is the story of a friendship that changes the course of rock history forever, of the fateful collision of minds between JB and KG that led to the creation of the precedent-shattering band Tenacious D, and of the two heroes' quest to find the fabled Guitar Pick Of Destiny...

Animals are strictly forbidden at Andi and her little brother Bruce's foster home. But for Friday, the adorable dog they secretly care for, they're ready to risk everything. They finally find him an ideal shelter, a huge abandoned hotel that Bruce transforms thanks to his engineering genius. In what has become an incredible paradise for dogs, Friday is soon joined by all kinds of furry friends, so many in fact that their barks alert the neighbors...and the local pound, who can't understand the disappearance of all the stray dogs. Andi and Bruce will have to call on all their friends and all their imagination to stop the hotel's secret from being discovered.

Homeless veteran Bob 'Drillbit' Taylor manages to enjoy life anyhow and even saves some cash for his dream, an 'all-paid' move to Alaska, even if that may take many years. His dream comes within reach when clever nerd Wade, has fat friend Ryan 'T-dog' and cocky shrimp Jim, all new to junior high-school, are bullied so badly by emancipated Filkins and his buddies that they advertise for a bodyguard. Only Drillbit seems affordable and not crazy, so he's hired and drains their pocket-money and home content. He's clueless how to protect them but gives them (bogus) self-defense classes.

Early thirty-something dentist Dr. Charlie Logan has never experienced true love, despite having had a number of girlfriends over the years. After an announcement by one of his ex-girlfriends as such at her wedding, Charlie gets a reputation as being a good luck charm. Every woman he has slept with has met and married her dream man immediately following. He is encouraged to exploit this reputation by his long time best friend, Dr. Stu Klaminsky, a sex obsessed, sex starved schlub who became a plastic surgeon just so that he could masturbate over the sight of women's breasts. Charlie doesn't want to be solely a stepping stone for women, which is how they end up treating him once he gains this reputation as a lucky charm, but rather one's true love. He believes the woman of his dreams is accident-prone Cam Wexler, who works as the penguin caretaker at the aquarium. Cam initially doesn't want to date Charlie because of his reputation as a one-night stand type of guy...