An American man returns to a corrupt, Japanese-occupied Shanghai four months before Pearl Harbor and discovers his friend has been killed. While he unravels the mysteries of the death, he falls in love and discovers a much larger secret that his own government is hiding.

Two actors, as their make up is applied, talk about the size of their parts. Then into the film: Laurence Sterne's unfilmable novel, Tristram Shandy, a fictive autobiography wherein the narrator, interrupted constantly, takes the entire story to be born. The film tracks between "Shandy" and behind the scenes. Size matters: parts, egos, shoes, noses. The lead's girlfriend, with their infant son, is up from London for the night, wanting sex; interruptions are constant. Scenes are shot, re-shot, and discarded. The purpose of the project is elusive. Fathers and sons; men and women; cocks and bulls. Life is amorphous, too full and too rich to be captured in one narrative.

Okwe, a kind-hearted Nigerian doctor, and Senay, a Turkish chambermaid, work at the same West London hotel. The hotel is run by Senor Sneaky and is the sort of place where dirty business like drug dealing and prostitution takes place. However, when Okwe finds a human heart in one of the toilets, he uncovers something far more sinister than just a common crime.

Sam Bell has a three year contract to work for Lunar Industries. For the contract's entire duration, he is the sole employee based at their lunar station. His primary job responsibility is to harvest and periodically rocket back to Earth supplies of helium-3, the current clean and abundant fuel used on Earth. There is no direct communication link available between the lunar station and Earth, so his only direct real-time interaction is with GERTY, the intelligent computer whose function is to attend to his day to day needs. With such little human contact and all of it indirect, he feels that three years is far too long to be so isolated; he knows he is beginning to hallucinate as the end of his three years approaches. All he wants is to return to Earth to be with his wife Tess and their infant daughter Eve, who was born just prior to his leaving for this job. With two weeks to go, he gets into an accident at one of the mechanical harvesters and is rendered unconscious...

Billionaire Nerio Winch is found dead, drowned. An obviously suspicious death as Nerio is the founder and majority shareholder of the powerful and sprawling W Group. Who will inherit this financial empire? Officially, Nerio had no family. But he had a secret he kept well-hidden: a son, Largo, adopted nearly thirty years before from a Bosnian orphanage. The only problem is this young heir has just been thrown in prison deep in the Amazon. Accused of drug trafficking, he claims he's innocent. Nerio murdered. Largo in prison. What if these two events were part of a plot to take control of the Winch empire?

50 years into the future, the Sun begins to die, and Earth is dying as a result. A team of astronauts are sent to revive the Sun - but the mission fails. Seven years later, a new team are sent to finish the mission as they are Earth's last hope.