College student Lewis decides to drive across the country to see Venna, a friend who doesn't know that Lewis is interested in her romantically. Unfortunately for his plans, Lewis gets saddled with his raucous-spirited older brother, Fuller, whose on-the-road pranks get the brothers and Venna sucked into a nightmare when a psychotic truckdriver takes offense.

A small, seemingly innocuous plastic reel of film leads surveillance specialist Tom Welles down an increasingly dark and frightening path. With the help of the streetwise Max, Welles relentlessly follows a bizarre trail of evidence to determine the fate of a complete stranger. As his work turns into obsession, he drifts farther and farther away from his wife, family and simple life as a small-town private eye.

A ticking-time-bomb insomniac and a slippery soap salesman channel primal male aggression into a shocking new form of therapy. Their concept catches on, with underground "fight clubs" forming in every town, until an eccentric gets in the way and ignites an out-of-control spiral toward oblivion.