After a plane crash where a boy is the only survival, the famous anchor Erika Lawson convinces her husband and cameraman Scott to adopt the child. They bring Donald home and Scott's father Big Jake offers to take care of him while the couple works. However, after a series of bizarre accidents that culminates with the death of Jake, the nanny Lucy Fir comes to the Lawson's home to work. However, Lucy is actually a follower of the Anti-Christ and together with Donald, they bring more tragedies to the Lawson's family.

In Louisiana, the thirty-five year old single mother Lavina delivers a baby boy and a monster in the evil Whateley House. Ten years later, Dr. Henry Armitage and his assistant Professor Fay Morgan discover that the page 751 of every copy of the Necronomicon is missing and The Black Brotherhood has summoned the gate keeper Yog Sothoth to leave the portal opened to the demons and ancient gods. They invite the arrogant and skeptical Professor Walter Rice that can translate the Necronomicon to help them to seek the book. Meanwhile Lavina's son Wilbur Whateley ages very fast and seeks the missing page to open the portal.

A happy newlywed marriage counselor's views on wedded bliss get thrown for a loop when she finds out her parents are getting divorced.